APPL1 and neoplasm: In addition, the expression levels of APPL1 in KIRC tumor cell lines Caki-1 and 769P were significantly lower than that of HK-2 cells (a normal proximal tubular cell line) (∗p < 0.05 and ∗∗p < 0.01) (Figures 2(c) and 2(d)), and this result was consistent with the gene expression distribution from CCLE database (Figure 2(e)).