SLC7A11 and rectum adenocarcinoma: Next, the GEPIA database was used to perform differential expression analysis of SLC7A11; we found that the expression of SLC7A11 was increased in colon adenocarcinoma (COAD), esophageal carcinoma (ESCA), lung squamous cell carcinoma (LUSC), and rectum adenocarcinoma (READ) and reduced in acute myeloid leukemia (LAML) (Figures 4(b) and 4(c)).