F2 and pyruvate carboxylase deficiency disease: The most observed causes of congenital thrombophilia are the Factor V Leiden (FVL) mutation, Prothrombin G20210A (also called prothrombin gene mutation [PGM]) gene mutation, Protein C (PC) deficiency, Protein S (PS) deficiency, and Antithrombin (AT) deficiency FVL and PGM together account for 50% to 60% of the hereditary cases (primary) with a hypercoagulative state in Caucasian populations [2].