Wu et al. observed that the synthetic locked nucleic acid form of EZN-2968 (RO7070179) sufficiently decreased the expression of HIF-1α and VEGF at the protein level and induced an apoptotic response when administered at a dose of 10 mg/kg in an orthotopic hepatocellular cancer (HCC) mouse model. This evidence concerns the gene HIF1A and hepatocellular carcinoma.