HIF1A and neoplasm: Supporting the role of HIF-1α in chemoresistance to 5-FU in gastric cancer, Nakamura et al. reported that the survival rate under 5-FU treatment was significantly lower in advanced-stage gastric cancer patients with diffuse expression of HIF-1α in the tumor, compared to the patients with HIF-1α negative tumors or HIF-1α positivity only in the invasive margins of the tumors (Nakamura et al., 2009).