In colorectal cancers the cWnt signaling cascade is activated, e.g., by upregulation of Wnt ligands, and in turn cWnt pathway suppressors, such as axin2, are upregulated (Fearon, 2011; Wu et al., 2012; Nie et al., 2020), which is coincident with the present and previous findings for USH1C/harmonin (Kobayashi et al., 1999). This evidence concerns the gene AXIN2 and colorectal cancer.