Moreover, although the 5-HT genes investigated in the present study have been choosen based on the previous reports indicating their involvement in the sensitivity to feedback, depressive disorder or antidepressant therapy (Savitz et al., 2009; Amodeo et al., 2014; Nautiyal and Hen, 2017; Phillips et al., 2018; Raval et al., 2021), one cannot exclude involvement of the other 5-HT receptors (5-HT1b, 5-HT1d, 5-HT2B, 5-HT3, 5-HT4, 5-HT6) in sensitivity to negative feedback. The gene discussed is HTR5A; the disease is depressive disorder.