Recent studies indicate that the human CYLD gene, which maps to chromosome 16q12.1, is a causative gene for frontotemporal dementia (FTD) and amyotrophic lateral sclerosis: patients carrying CYLD mutations (CYLD p.Met719Val) display prominent memory impairment (Dobson-Stone et al., 2013, 2020; Tabuas-Pereira et al., 2020). This evidence concerns the gene CYLD and frontotemporal dementia.