Chinese medicine and exercise have been shown to enhance the PI3K/Akt pathway, regulate synaptic plasticity, resist apoptosis and inflammation, promote the regression of fear memory, increase 5-HT levels in the hippocampus, and alleviate PTSD symptoms (Ling et al., 2020; Zhang et al., 2020). The gene discussed is AKT1; the disease is post-traumatic stress disorder.