An additional PKA phosphorylation site on the CaV1.2 CT at position Ser1928 is rapidly phosphorylated in cardiac myocytes during β-adrenergic regulation and has an important role in mediating CaV1.2 upregulation by β-adrenergic stimulation in neurons and increased vascular reactivity in patients with diabetes (De Jongh et al., 1996; Hulme et al., 2006b; Patriarchi et al., 2016; Nystoriak et al., 2017). The gene discussed is CACNA1C; the disease is diabetes mellitus.