Interestingly, comparable injuries were observed with each corresponding case that accompanied hydrodynamic delivery of IDH2 plasmid vectors, i.e., there were no significant differences between the levels of injury observed between the AKI and AKI + IDH2 groups (p ≮ 0.05), and the mild AKI and mild AKI + IDH2 groups (p ≮ 0.05). This evidence concerns the gene IDH2 and acute kidney injury.