Urinary NGAL (uNGAL) seems to be more sensitive than plasma NGAL (pNGAL) (19–23), and uNGAL-to-creatinine ratio (UNCR) has been shown to be a specific and sensitive marker for naturally occurring AKI in dogs, although it is also increased in chronic kidney disease (CKD) (24, 25). The gene discussed is LCN2; the disease is chronic kidney disease.