Along these lines, it appears as a particularly interesting therapeutic avenue to target the ghrelin system as an adjunct to psychotherapy to improve treatment efficacy: While cognitive behavioral therapy, which relies on fear extinction, is a gold-standard treatment for anxiety disorders and PTSD, many patients experience only limited treatment success and relapse after time (23, 24), which is likely due to individual deficits in the ability to acquire, consolidate or retrieve extinction memories (25, 26). The gene discussed is GHRL; the disease is post-traumatic stress disorder.