Li et al. included the SNPs rs9937053 and rs185932673 in their MR analyses, however, we removed them to avoid the bias caused by horizontal pleiotropy and imprecise statistical estimates since the SNP rs9937053 is located in the FTO gene, which is closely associated with obesity and the allele frequency of SNP rs185932673 is extremely low (< 0.01), which might cause statistical issues. This evidence concerns the gene FTO and obesity due to melanocortin 4 receptor deficiency.