The first description of ALS18 was made by Wu et al. (3), who reported 22 patients with ALS, carrying 4 missense variants [c.211T > G (p.Cys71Gly); c.341T > C (p.Met114Thr); c.350A > G (p.Glu117Gly) and c.353G > T (p.Gly118Val)] in the PFN1 gene. Here, PFN1 is linked to amyotrophic lateral sclerosis.