The novel variant, described in this study [c.92T > G (p.Val31Gly)], allows to further strengthen the association of pathogenic variants in the PFN1 gene (which have been reported to induce disturbed dynamics of microtubules and/or troubled coordination between actin and microtubule filaments in motoneurons) with development of ALS18 (16). Here, PFN1 is linked to amyotrophic lateral sclerosis type 18.