In the same study, a few SVAs in the LD blocks of GWAS SNP signals for AD, PD, MS, and ALS were identified; the deletion of SVAs around BIN1 (AD gene) and BCKDK (PD gene) alters epigenome and nearby gene expression (Table 2; van Bree et al., 2022). This evidence concerns the gene BCKDK and Alzheimer disease.