APP and Alzheimer disease: In a study from France that included 12 unrelated individuals with autosomal dominate early-onset AD (EOAD), 70 unrelated individuals with familial LOAD, and 100 health controls, the APP duplications ranging from 0.58 to 6.37 Mb were found in five individuals with autosomal-dominant EOAD (Table 1; Rovelet-Lecrux et al., 2006).