CPNE4 and Alzheimer disease: Two studies found genome-wide significant CNVs using alternative phenotypes (Age of onset and AD with psychosis): Szigeti et al. (2013) identified five significant regions (FDR < 0.05) ranging from 3.6 to 24.8 Kb that were related to the age of onset in AD, including a intragenic deletion in CPNE4 (Table 1).