Specifically, there was an abundance of M2 macrophages, resting dendritic cells, resting mast cells, monocytes, eosinophils, activated natural killer cells, CD8+ T cells, regulatory T cells, CD4+ memory resting T cells and plasma cells in adjacent normal colon tissue, compared to CRC (p < 0.0001), (Figure 1A). This evidence concerns the gene CD8A and colorectal carcinoma.