HGF and colitis: Bone marrow-derived MSCs reduced fibrotic-associated activities such as collagen deposition and EMT in the TNBS-induced colitis mouse model [7], while adipose-derived MSCs mediated the downregulation of fibrogenesis via controlling ECM turnover through the induction of a decreased expression of profibrotic proteins and genes by releasing hepatocyte growth factor (HGF) and tumor necrosis factor-stimulated gene 6 (TSG-6) in colorectal fibrosis [8].