One of the most notable features of Drosophila as a model organism is the availability of human-homologs cancer-related signaling pathways such as epidermal growth factor receptor (EGFR), Hedgehog (Hh), the Janus-activated kinase (JAK)-signal transducer and activation of transcription (STAT), nuclear factor κB (NF-κB), Notch, and Salvador-Warts-Hippo (SWH). Here, EGFR is linked to cancer.