As secondary hypertension results from the vasculature’s response to angiotensin-I and the effect of aldosterone on the renal collecting system, treatment with angiotensin-converting enzyme inhibitors or aldosterone receptor blockers is typically effective at counteracting renin’s downstream effects, given the cautious use of angiotensin-converting enzyme inhibitor in the setting of acute kidney injury16. The gene discussed is ACE; the disease is secondary hypertension.