PIK3CA and neoplasm: 20 of 34 ICDRGs were differentially expressed between BRCA and normal samples, among which BAX1, CALR, PDIA3, and HSP90AA1 were overexpressed, while IFNGR1, TLR4, IL-6, IL1R1, NT5E, and PIK3CA were lowly expressed in tumor compared to normal samples (Figure 2A).