TP53 and B-cell chronic lymphocytic leukemia: Likewise, disease and patient characteristics beyond TP53 and IGHV must be validated or newly defined, and potentially integrated in new prognostic models, since risk scores like the CLL International Prognostic Index (CLL-IPI) and the Continuous Individualized Risk Index (CIRI)) were developed using data from patients treated by chemoimmunotherapy with re-evaluation in the context of novel agents pending (41, 42).