Among them, the anti-tumor immune cells, such as activated CD8 T cell, central memory CD4 T cell, effector memory CD8 T cell, natural killer cell, natural killer T cell, type 17 T helper cell and type 2 T helper cell were reduced in high risk group, while the protumor immune cell, such as MDSC was also reduced in high risk group. Here, CD8A is linked to neoplasm.