MTOR and Miyoshi myopathy: In addition, we found that the estimated IC50 of AICAR (Acadesine, AMPK activator), ATRA (all-trans-retinoicacid), GDC0941 (PI3K inhibitor), JNK.Inhibitor.VIII, rapamycin (mTOR inhibitor) and thapsigargin (ATPase inhibitor) were also lower in MM patients in the high risk group based on our risk signature.