The p53 protein, which we all known serving as a critical tumor suppressor, could mediate cell cycle arrest, senescence and apoptosis, previous study found that p53 could inhibit cystine uptake and sensitize cells to ferroptosis by repressing expression of SLC7A11 (a component of the cystine/glutamate antiporter) (12). The gene discussed is TP53; the disease is neoplasm.