GNG4 and osteosarcoma: In the present study, DEGs between normal and osteosarcoma samples were screened through OS chip data from the GEO database, and then DEGs related to G protein were obtained via intersection with G protein family genes: G protein subunit γ 12 (GNG12) (low expression) and G protein subunit γ 4 (GNG4) (high expression), which are both γ subunits of the G protein.