Some important key tumor regulators, RAS, TP53, NRF2, and HIF, are able to regulate the susceptibility of tumor cells to ferroptosis by affecting the metabolism associated with iron, lipids, or ROS (70–74).SLC7A11 is also a biomarker associated with HPV, with low levels of SLC7A11 expression in HPV-positive cancer tissues, and HPV16-derived E6 and E7 proteins inducing EMT activate the expression of transcription factors (e.g., Slug, Twist, ZEB1 and ZEB2) while decreasing GSH levels and sensitizing tumor cells to ferroptosis elicited by erastin (75). The gene discussed is ZEB2; the disease is neoplasm.