In this study, we identified exclusive mitochondria-related DEGs in paediatric AML and developed a prognostic gene signature including 3 genes (SDHC, CLIC1, and SLC25A29). The gene signature risk score was additionally found to be independently predictive of survival along with established ELN risk stratification with improved predictive ability over clinical risk categorization. The gene discussed is SLC25A29; the disease is acute myeloid leukemia.