In detail, the R:S ratio in the VH CDR1 of IGHV1-18 and IGHV5-51 gene rearrangements in patients with IgG MM was significantly higher compared to the respective IgA MM patients (10.5 in IgG versus 0.7 in IgA for IGHV1-18 rearrangements and 2.5 in IgG versus 0 in IgA for IGHV5-51 rearrangements, respectively; p-values <0.05 in both cases). The gene discussed is CD79A; the disease is Miyoshi myopathy.