HRAS is a known oncogene related to several different cancers, among them Costello syndrome, a rare condition predisposing to tumours in different parts of the body, epidermal tumours, head and neck cancer, bladder carcinoma, and with ovarian carcinoma patients, but was also identified in the healthy controls The variants frequency is not annotated in ClinVar so that it also requires further characterization on the populational level. The gene discussed is HRAS; the disease is Costello syndrome.