Several genes in which the variants were identified, are related to hereditary cancer syndromes, such as PALB2, related to ovarian and breast cancer or JAK2 (c.3323A>G, p.Asn1108Ser) associated with lung adenocarcinoma, myeloproliferative neoplasm, breast invasive ductal carcinoma, polycythemia vera, and colon adenocarcinoma (Supplementary Table 5). Here, JAK2 is linked to Inherited cancer-predisposing syndrome.