For example, the variant in PALB2 (c.3103A>G (p.Ile1035Val)) gene reported as having conflicting interpretations of pathogenicity in ClinVar and suggested of being pathogenic in the literature (46) was present in healthy individuals as well as in breast cancer individuals from the extended cohort Our study confirmed the presence of this PALB2 (c.3103A>G (p.Ile1035Val)) variant in the Polish core cohort in a very high AF (12.3%). This evidence concerns the gene PALB2 and breast carcinoma.