RPN1 and esophageal adenocarcinoma: Other variants reported as pathogenic/likely pathogenic/with conflicting interpretations of pathogenicity according to the ClinVar were located in the following genes: MSH6 associated with Lynch Syndrome i.e. hereditary non-polyposis colorectal cancer (23), PIK3CB, which is altered in 1.62% of all cancers such as colon adenocarcinoma, prostate adenocarcinoma, lung adenocarcinoma, breast invasive ductal carcinoma; RPN1 altered in 0.19% of all cancers with high grade ovarian serous adenocarcinoma, colon adenocarcinoma, oesophageal adenocarcinoma, bladder urothelial carcinoma (24).