In terms of non-hematological AEs (fatigue, rash, nausea/vomiting, diarrhea, hypoalbuminemia, abnormal liver function, peripheral neuropathy, esophageal perforation, pneumonia), and the incidence of pneumonia (33.3% vs. 13.7%, P = 0.036) in Anti-PD-1+CRT group was higher than that in CRT group. This evidence concerns the gene PDCD1 and Hypoalbuminemia.