MCPH1 and breast carcinoma: Interrogation of The Cancer Genome Atlas (TCGA; cBioPortal Cancer Genomics database http://cancergenome.nih.gov/) has identified alterations in MCPH1/BRIT1 in many malignant tumours such as breast cancer (~5%), prostate cancer (5.7%), bladder urothelial carcinoma (8%), lung cancer (7%), ovarian cancer (7%), liver cancer (7%) and colorectal adenocarcinoma (7.4%) (Figure 3).