The average peak area values of FBLN2 (aa330–349 and aa365–378)/T, CSF1 (aa370–395)/(T + di-ST), MRC1 (aa1215–1229)/T, and C7 (aa692–701)/di-ST in the serum of patients with advanced CRC were significantly increased (p < 0.01). The gene discussed is CSF1; the disease is colorectal carcinoma.