The inhibitor sensitivity exhibited by the murine KRASG12C cell lines (Figure 1) overlapped with the most sensitive human lung cancer cell lines bearing KRASG12C, indicating that co-occurring mutations present in many of the human lines markedly reduce their sensitivity to MRTX-1257 and AMG-510 similar to the activity of GTPase-deficient NRAS in parental LLC cells. This evidence concerns the gene NRAS and lung carcinoma.