Compared with the common features of Chinese ALS population, the patients only carrying rare, putative pathogenic TP73 mutations showed a later age at onset (61.5 vs. 54.3 years), the lower disease duration (19.25 months vs. 71 months), and the higher spinal onset rate (100% vs. 76.6%) (Chen et al., 2015; Liu et al., 2021). The gene discussed is TP73; the disease is amyotrophic lateral sclerosis.