Interestingly, we discovered that exon 14 of the TP73 gene appeared to be a mutant hotspot in the Chinese ALS cohort, unlike the earlier studies where the mutated sites were relatively clustered in exons eight, nine, ten, eleven and twelve (Figure 1A; Russell et al., 2021; Dilliott et al., 2022). Here, TP73 is linked to amyotrophic lateral sclerosis.