Considering the burden of multiple variants in ALS-causing genes on the disease expression, including the age at onset, progression rate, and survival, we separated these six patients into two subgroups for further clinical phenotype analysis (one subgroup with only TP73 mutations, the other with multiple mutations in both TP73 and other ALS-related genes) (Cady et al., 2015; Pang et al., 2017; Naruse et al., 2019). The gene discussed is TP73; the disease is amyotrophic lateral sclerosis.