Notably, two of the six patients (patient A0048 and patient S7918) had multiple variants in ALS-related genes with uncertain pathogenicity (patient A0048: KIF5A c.A86G: p.K29R and TP73 c.1613G > A: p.R538H; patient S7918: CCNF c.2199delC: p.D733fs and TP73 c.187G > A: p.A63T), and the remaining four patients only had TP73 mutations. The gene discussed is CCNF; the disease is amyotrophic lateral sclerosis.