GBA1 and Parkinson disease: This study has several strengths, including (1) establishing the first GBA-PD longitudinal cohort in a Chinese population; (2) demonstrating that the pattern of rapid motor and cognitive progression in GBA-PD is characterized by severely impaired bradykinesia, axial impairment, and visuospatial/executive function; and (3) screening the entire GBA gene without GBAP1 interference for more accurate variant-specific analysis.