Increased dietary cholesterol intake promotes Abeta formation and AD pathology (Pappolla et al., 2003; Ghribi et al., 2006; Ismail et al., 2017; Liu et al., 2018; Wu et al., 2022) and tau hyperphosphorylation (Bhat and Thirumangalakudi, 2013; Park et al., 2013) and cognitive impairment (Umeda et al., 2012). Here, MAPT is linked to Alzheimer disease.