Triple-transgenic AD (3 × Tg-AD) mice exhibit myelin abnormalities similar to FAD patients; and the PS1 (M146V) mutation predisposes mouse OPCs to Aβ(1-42) -induced alterations in cell differentiation and function that results in an abnormal distribution of myelin basic protein (MBP) (Desai et al., 2011). Here, PSEN1 is linked to Alzheimer disease.