C9orf72 and amyotrophic lateral sclerosis: Meanwhile, 128 miRNAs were dysregulated in patients with C9orf72-mutated ALS, including 84 upregulated and 44 downregulated miRNAs, based on our cutoff values for differential expression (fold change ≥ 1.2; adjusted p-value < 0.05) (Figures 2A, B).