Interestingly, 11 miRNAs, including 4 upregulated and 7 downregulated miRNAs, were differentially expressed in patients with SOD1-mutated ALS and C9orf72-mutated ALS with overlapping (Supplementary Figure 2 and Supplementary Table 2), which might indicate a common pathology involved in ALS. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.