C9orf72 and amyotrophic lateral sclerosis: Interestingly, hsa-miR-1306-3p showed significant downregulation in patients with SOD1 and C9orf72 gene mutations, compared to patients with SALS and HCs (SALS vs. SOD1-ALS: p = 0.0021, SALS vs. C9orf72-ALS: p = 0.0032, SOD1-ALS vs. HCs: p = 0.002, C9orf72-ALS vs. HCs: p = 0.0032) and no statistical significance was found between patients with SALS and HCs (p = 0.807) (Figure 3A).