IFNG and malaria: Interestingly, the Tfh cell-suppressive nature of Type I IFN signalling observed by the Butler group was determined to be due to Type 1 regulatory (IFNγ/IL-10 producing T cells; Tr1)-intrinsic Type I IFN signalling [104], indicating that there may be multiple mechanisms in how Type I IFN signalling modulates Tfh cell responses in malaria.