MRC1 and hepatocellular carcinoma: (Luo et al., 2021) As a result, the HCC TME is enriched in fatty acids and lipid derivatives, an environment that can promote a pro-tumoral phenotype in tumor-associated macrophages (TAM), characterized by the expression of CD206, IL-6, vascular endothelial growth factor A (VEGF-A), matrix metalloproteinase (MMP) 9 and ARG1.