(Colonna, 2003) Mechanistically, TREM2 is associated with and signals via DAP12, which downregulates the transcription of inflammatory genes like TNFA, IL1B, and NOS2. (Takahashi et al., 2007) TREM2+ macrophages seem to be a highly conserved population, as macrophages with closely similar gene signatures have been described in different tissues and diseases, such as adipose tissue, atherosclerosis and Alzheimer disease. This evidence concerns the gene TREM2 and Alzheimer disease.