(Ehling and Tacke, 2016; Mulder et al., 2021) Furthermore, strong evidence from imaging mass cytometry in human melanoma, suggest that CXCL9 is a major chemoattractant for cytotoxic CD8+ T cells, and CXCL9 and CXCL10 expressing cells accumulating in areas of active anti-tumor activity. This evidence concerns the gene CD8A and melanoma.