(Sharma et al., 2020; Mulder et al., 2021) Interestingly, the aforementioned HES1+ TAM population was mainly located within the tumor, while the monocyte-derived TAM subpopulations rather accumulated in the tumor periphery, which is in good agreement with previous observations that CCR2+ TAMs with an inflammatory and pro-angiogenic gene signature accumulated at the tumor border, while CD163+ TAMs were predominantly found in the tumor center. The gene discussed is HES1; the disease is neoplasm.