ST8SIA3 (alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3) is involved in neurite growth, cell migration, and synaptic plasticity (Goodman et al., 1997; Lee et al., 1998; Eckhardt et al., 2000; Lin et al., 2019) and plays an important role in the development of Huntington’s disease, schizophrenia, and Parkinson’s disease (Belarbi et al., 2020; Moll et al., 2020). Here, ST8SIA3 is linked to Huntington disease.