Interestingly, a large number of genes that were implicated in disease processes by the iPSC-neuronal model were changed in opposite directions in the PSP (n = 20) and AD brains (n = 51; Figure 5B), leading to a similar clustering of these brains with the iPSC-neuronal model but to a lesser extent than what we observe in brains from MAPT mutation carriers (Figure 5C). This evidence concerns the gene MAPT and Alzheimer disease.