PRICKLE2 and neurodegenerative disease: We report that several genes from the mutant iPSC-neurons were also altered at disease end-stage in the Tau-P301L mouse model of tauopathy: CALB1, PLK2, CELSR1, CHRDL1, PRICKLE2, and ST8SIA3. PLK2 (Polo like kinase 2) is associated with synaptic plasticity and prevention of cell death in neurodegenerative diseases (Kauselmann, 1999; Seeburg et al., 2005; Seeburg et al., 2008; Li et al., 2014; Weston et al., 2021).