MAPT and Alzheimer disease: Wnt signaling has been previously shown to be associated with the MAPT IVS10 + 16 mutation (Harrison-Uy and Pleasure, 2012) and linked to several neurodegenerative disorders such as AD and FTLD (Korade and Mirnics, 2011; Rosen et al., 2011; Riise et al., 2015; Verheyen et al., 2018; Bottero et al., 2021).