AKR1B10 and hepatocellular carcinoma: This study highlights the following major findings: 1) AKR1B10 was identified as a key gene in the progression of PBC using bioinformatics analysis; 2) high expression of hepatic AKR1B10 might promote the progression of PBC to HCC; 3) increase in hepatic AKR1B10 expression was associated with PBC severity; 4) levels of hepatic AKR1B10 were positively correlated with the circulatory parameters associated with hepatic function in patients with PBC.