Moreover, given its role in detoxification, AKR1B10 was shown to contribute to the chemoresistance acquisition against some anti-cancer drugs, such as daunorubicin, and idarubicin (Zhong et al., 2011) (Morikawa et al., 2015), and cisplatin (Matsunaga et al., 2016). This evidence concerns the gene AKR1B10 and cancer.