Although the molecular mechanisms underlying hepatocarcinogenesis remain poorly clarified, AKR1B10 may play a pivotal role in HCC through several mechanisms, including lipogenesis, oxidative stress, detoxification of cytotoxic reactive carbonyls, and regulation of sphingosine-1 phosphate and retinoic acid (DiStefano and Davis, 2019). This evidence concerns the gene AKR1B10 and hepatocellular carcinoma.