Interestingly, many TFs that potentially regulate the expression of AKR1B10 according to our analysis, such as KDM5B (Wang et al., 2016; Gong et al., 2018), TRIM28 (Zhang et al., 2021; Han et al., 2022; Zhang et al., 2022), and PHF8(Zhou et al., 2018), had been previously identified to promote the development of HCC. This evidence concerns the gene AKR1B10 and hepatocellular carcinoma.