AKR1B10 and cancer: In addition, AKR1B10 may be upregulated by the activation of some signal transduction pathways, such as MAPK (Nishinaka et al., 2015), Nrf2 (Nishinaka et al., 2017), and AP-1 (Cheng et al., 2018) pathways, and promote the proliferation and migration of cancer cells.