AKR1B10 and hepatocellular carcinoma: AKR1B10 expression was reported to be significantly increased in nonalcoholic steatohepatitis, where it promotes the progression of nonalcoholic steatohepatitis to HCC through several mechanisms, such as by contributing to lipogenesis and facilitating the detoxification of reactive carbonyl species derived from lipid peroxidation (Bitter et al., 2015; Endo et al., 2021).