Growing evidence supports that AKR1B10 is involved in the occurrence and progression of many cancers, such as HCC (Ye et al., 2019), breast cancer (Qu et al., 2021), non-small cell lung cancer (Fukumoto et al., 2005), and pancreatic cancer (Chung et al., 2012). Here, AKR1B10 is linked to hepatocellular carcinoma.