F2RL1 and neoplasm: In addition, TFPI inhibits the intracellular activity of FXa and the TF/FVIIa/FXa complex by inhibiting the activation of the protease activated receptor 2 (PAR-2) (Camerer et al., 2000), which in turn induces downstream signaling leading to the production of pro-angiogenic factors, inflammatory cytokines and growth factors, all them essential to support tumor cell migration and metastasis (Unruh and Horbinski, 2020).