In this regard, endogenous regulator of the coagulation cascade, TFPI, plays an important role in stopping coagulation and cancer progression by inhibiting the extrinsic tenase complex formed by the TF, the active factor VII (FVIIa), and the active factor X (FXa) on the tumor cells surface, and the FXa alone through its first (K1) and second (K2) Kunitz-domain, respectively (Crawley and Lane, 2008). Here, TF is linked to neoplasm.