In a similar fashion, we believe that information theoretical approaches can be constructed to model within the proposed framework other significant hallmarks of AD, including accumulation of tangles of abnormally hyperphosphorylated tau (Mazanetz and Fischer, 2007), degeneration of noradrenergic neurons of the locus coeruleus (Chen et al., 2022) and cholinergic neurons in the basal forebrain (Auld et al., 2002), and development of insulin resistance (Ferreira et al., 2018). Here, MAPT is linked to Alzheimer disease.