Similar to EZH2, several mutations in EED have also been identified in patients with Weaver syndrome (Cooney et al., 2017; Cyrus et al., 2019; Griffiths et al., 2019), while mutations in SUZ12 have been associated with a Weaver-like syndrome presenting with macrocephaly, postnatal overgrowth, and skeletal abnormalities (Imagawa et al., 2017, 2018). The gene discussed is EED; the disease is Weaver syndrome.