ASH1L and microcephaly: Mutations in ASH1L have also been reported in severe forms of ASD, presenting with ID, seizures, speech difficulties, and in a small number of cases microcephaly and macrocephaly (Homsy et al., 2015; Wang et al., 2016; Faundes et al., 2017, 2018; Okamoto et al., 2017; Stessman et al., 2017).