APC2 and Sotos syndrome: In humans, mutations in Adenomatous Polyposis coli 2 (APC2), a protein with a crucial role in the control of neuronal migration and axon guidance (Mimori-Kiyosue et al., 2000; Shintani et al., 2009, 2012), have been identified by whole exome sequencing as an additional cause of Sotos syndrome (Almuriekhi et al., 2015).