PTEN and cancer: CDKN2A, IKZF1, ETV6, RUNX1, and FLT3 were the top genes mutated in leukemias, while somatic alterations in ALK, NF1, and PTEN primarily occurred in solid tumors, suggesting that the driver alterations are either common to cancer (e.g., cell cycle) or specific to pediatric cancer histotype (Ma et al., 2018).