These include KCNA2, KCNA3, KCNA10, LAMTOR5, PROK1, RBM15, and SLC16A4. Potassium voltage-gated channel gene expression have previously been shown to change in expression in the heart in response to hypothyroidism in rats (Nishiyama et al., 1998). This evidence concerns the gene SLC16A4 and hypothyroidism.