For instance, PDHB is higher in breast invasive carcinoma (BRCA), LIHC, lung adenocarcinoma (LUAD), and uterine corpus endometrial carcinoma (UCEC) than in their corresponding normal tissues while lower in colon adenocarcinoma (COAD), ESCA, head and neck squamous cell carcinoma (HNSC), kidney renal clear cell carcinoma (KIRC), kidney renal papillary cell carcinoma (KIRP), lung squamous cell carcinoma (LUSC), and rectum adenocarcinoma (READ) than in paired normal samples. The gene discussed is PDHB; the disease is head and neck squamous cell carcinoma.