We explored the expression status of CRGs in HCC, and the results indicated that most genes were upregulated in HCC compared to normal tissues except for FDX1, including LIAS, LIPT1, DLD, DLAT, PDHA1, PDHB, MTF1, GLS, CDKN2A (Figure 3A). The gene discussed is LIPT1; the disease is hepatocellular carcinoma.