Xu et al. (2018) demonstrated overexpression of lncRNA SNHG16 suppressed HCC growth and chemoresistance. LncRNA MFI2-AS1 plays a positive role in HCC progression and distant metastasis via upregulating the expression level of FOXM1 (Wei et al., 2020). Accumulating research or bioinformatic analysis identified lncRNAs can influence the phenotype of HCC by interacting with cell death, including pyroptosis, ferroptosis, and apoptosis (Mao et al., 2018; Zhang et al., 2022b). The gene discussed is FOXM1; the disease is hepatocellular carcinoma.