We explored the expression status of CRGs in HCC, and the results indicated that most genes were upregulated in HCC compared to normal tissues except for FDX1, including LIAS, LIPT1, DLD, DLAT, PDHA1, PDHB, MTF1, GLS, CDKN2A (Figure 3A). The gene discussed is CDKN2A; the disease is hepatocellular carcinoma.