TBPL2 and acute pancreatitis: Previous studies have shown that tRF3-Thr-AGT targets Btg2, Cd44, Zbp1, etc. Downregulated tRF3-Thr-AGT was shown to be involved in pancreatic acinar intracellular trypsinogen activation (PAITA), which is an important event in the early stage of acute pancreatitis (AP) (Yang et al., 2022).