Previous studies have shown that tRF3-Thr-AGT targets Btg2, Cd44, Zbp1, etc. Downregulated tRF3-Thr-AGT was shown to be involved in pancreatic acinar intracellular trypsinogen activation (PAITA), which is an important event in the early stage of acute pancreatitis (AP) (Yang et al., 2022). This evidence concerns the gene ZBP1 and acute pancreatitis.