Finally, we compared the predictive prognostic ability of composite score with IRGPI, m6A risk score, TIS, TIDE, IFNG, MSI, Merck18, CD274, CD8, Dysfunction, Exclusion, MDSC, CAF, and TAM (M2) scores on the HNSCC cohort in TCGA. The gene discussed is IFNG; the disease is head and neck squamous cell carcinoma.