It was founded that cyclophosphamide activated the expression of p53-p66Shc pathway-related proteins by inducing the expression of endogenous lncRNA-Meg3 and ultimately possessed an inhibiting effect on granulosa cells, inducing ovarian insufficiency in a mouse model of ovarian dysfunction induced by cyclophosphamide (Xiong et al., 2017). This evidence concerns the gene MEG3 and ovarian dysfunction.