Of the 83 TWAS-significant genes, 15 had significant associations with more than ten tissues, including KCNK3, SH3D19, AGBL5-IT1, ASXL2, BMP3, DPYSL5, USP38, ENPEP, RP11-286E11.2, LEF1, RAB10, TCF23, SNORA70F, MLPH, and TMEM214. These 15 genes together contributed 310 (64.2%) of the 483 significant loci, suggesting that they are crucial in essential hypertension. This evidence concerns the gene TMEM214 and hypertensive disorder.