Furthermore, in another research, the utilization of multilayer omics approach discerning various protein networks (such as MDK, NTN1, SMOC1, SLIT2, and HTRA1) during progression of AD by profiling 14,513 proteins and 34,173 phosphosites in the human brain with mass spectrometry (Bai et al., 2020) (Table 1). The gene discussed is SMOC1; the disease is Alzheimer disease.