APOE and Alzheimer disease: Additionally, the lipid content of membrane lipid rafts is directly linked to amyloidogenesis, a significant pathogenetic component for AD (Ehehalt et al., 2003), which have a higher concentration of saturated fatty acids (FAs) than polyunsaturated fats (PUFAs) and sphingolipids, which operate as platforms for Aβ associations with tau and ApoE to facilitate the formation of A oligomers and hyperphosphorylation (Di Paolo and Kim 2011; Huynh et al., 2017).